CDK6 polyclonal antibody
产品名称： CDK6 polyclonal antibody
英文名称： CDK6 polyclonal antibody
产品编号： PAB2916
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDK6.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDK6.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation.
Chen Q, Lin J, Jinno S, Okayama H.Oncogene. 2003 Feb 20;22(7):992-1001.
- 2.
- Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.
Morris M, Hepburn P, Wynford-Thomas D.Oncogene. 2002 Jun 20;21(27):4277-88.
- 3.
- Translocation t(2;7)(p12;q21-22) with dysregulation of the CDK6 gene mapping to 7q21-22 in a non-Hodgkin's lymphoma with leukemia.
Brito-Babapulle V, Gruszka-Westwood AM, Platt G, Andersen CL, Elnenaei MO, Matutes E, Wotherspoon AC, Weston-Smith SG, Catovsky D.Haematologica. 2002 Apr;87(4):357-62.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CDK6 polyclonal antibody (Cat # PAB2916) in, from left to right, Ramos, Jurkat, HepG2, and HL-60 cell line lysates. CDK6 (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with CDK6 polyclonal antibody (Cat # PAB2916) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 1021
- Protein Accession#:
- Q00534
- Gene Name:
- CDK6
- Gene Alias:
- MGC59692,PLSTIRE,STQTL11
- Gene Description:
- cyclin-dependent kinase 6
- Omim ID:
- 603368
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. [provided by RefSeq
- Other Designations:
- cell division protein kinase 6
- Related Disease
- Adenocarcinoma
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Breast cancer
- Breast Neoplasms
- Carcinoma, Medullary
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Growth Disorders
- Head and Neck Neoplasms