Gle1 polyclonal antibody
产品名称： Gle1 polyclonal antibody
英文名称： Gle1 polyclonal antibody
产品编号： PAB16683
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of Gle1.
- Immunogen:
- A synthetic peptide corresponding to internal region 14 amino acids of human Gle1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.
Kendirgi F, Rexer DJ, Alcazar-Roman AR, Onishko HM, Wente SR.Mol Biol Cell. 2005 Sep;16(9):4304-15. Epub 2005 Jul 6.
- 2.
- The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.
Rayala HJ, Kendirgi F, Barry DM, Majerus PW, Wente SR.Mol Cell Proteomics. 2004 Feb;3(2):145-55. Epub 2003 Nov 25.
- 3.
- The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.
Watkins JL, Murphy R, Emtage JL, Wente SR.Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6779-84.
- Entrez GeneID:
- 2733
- Protein Accession#:
- NP_001003722
- Gene Name:
- GLE1
- Gene Alias:
- GLE1L,LCCS,LCCS1,hGLE1
- Gene Description:
- GLE1 RNA export mediator homolog (yeast)
- Omim ID:
- 603371
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- GLE1 RNA export mediator homolog,GLE1 RNA export mediator-like,GLE1-like, RNA export mediator,OTTHUMP00000022280,OTTHUMP00000022281
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